Seville 2022 

D Sanchez-Martinez

Josep Carreras Leukemia Research Institute; Red Española de Terapias Avanzadas (TERAV) - Instituto de Salud Carlos III (ISCII) (RICORS, RD21/0017/0029)

Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in Acute Myeloid Leukemia

C Bueno

Josep Carreras Leukemia Research Institute. Campus Clinic. Barcelona. Spain; Centro de Investigación Biomédica en Red en Oncología (CIBER-ONC), ISCIII, Madrid, Spain; Red Española de Terapias Avanzadas (TERAV)-Instituto de Salud Carlos III (ISCIII) (RICORS, RD21/0017/0029), Madrid, Spain.

CD34⁺CD19⁻CD22⁺ B-cell progenitors might underlie phenotypic escape in patients treated with CD19-directed therapies

B Blanco

Instituto de Investigación Hospital 12 de Octubre (i+12); Hospital Universitario 12 de Octubre; Red Española de Terapias Avanzadas (TERAV), Instituto de Salud Carlos III

Overcoming CAR-mediated CD19 downmodulation and leukemia relapse with T lymphocytes secreting anti-CD19 T-cell engagers

M Tristán-Manzano

LentiStem Biotech

Physiological (TCR-like) regulated lentiviral vectors: a platform for the generation of improved CAR-T cells

L García-García

Laboratorio de investigación en Oncohematología, Fundación de Investigación Biomédica, Hospital Infantil Universitario Niño Jesús, Madrid, 28009, Spain

Use of anti-GD2 (Dinutuximab) as a target for CAR-T cells immunotherapy in Neuroblastoma

B Díez

Division of Hematopoietic Innovative Therapies, Biomedical Innovation Unit, Centro de Investigaciones Energéticas Medioambientales y Tecnológicas (CIEMAT), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) and Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid, Spain

Transposon-based CAR-T cells for lymphoma treatment

M Cortijo-Gutiérrez

GENyO

Creation of next generation CAR-T by Repurposing endogenous immune pathways

A López

CIEMAT/CIBERER

Generation of CAR-T cells for the treatment of squamous cell carcinomas in Fanconi anemia patients

P Justicia-Lirio

GENyO- Centro de Genomica e Investigacion Oncologica: Pfizer / Universidad de Granada / Junta de Andalucia; LentiStem Biotech

Development of 4th generation regulated CAR-T cells (iTRUCKs) targeting pancreatic solid tumors

K Pavlovic

GENyO- Centro de Genomica e Investigacion Oncologica: Pfizer / Universidad de Granada / Junta de Andalucia; Instituto Maimónides de Investigación Biomédica de Córdoba

TCR/HLA-I double knockout CAR-T cells maintain lytic ability with reduced allogenicity

P Garcia-Rodriguez

Instituto de Salud Carlos III

Challenges of CAR-T cells in solid tumours: modelling immunotherapy with 3D osteosarcoma cultures

P Barbao

IDIBAPS

Chronic antigen exposure induces CAR-T cell loss of function and a dysregulated gene expression profile leading to treatment failure in solid tumors