microRNAs (miRNAs) have recently gained attention in the field of host-parasite interaction after it has been proven that several organisms such as viruses and insects rely on their use for their infection to succeed. Although these miRNAs are still not well characterized, it is known that they alter host response to the attack. In this regard, a set of miRNAs have been sequenced from invertebrate saliva and several cancer and proliferation related targets have been reported after an in silico prediction. In vitro proliferation assays on A-375 melanoma cell line show an inhibition of up to 61% in transfected cells as compared to the mock miRNA sequence.  Annexin V and IP assays were used to evaluate the effect of miRNA transfection on apoptosis levels and cell cycle state. These experiments showed an increase in apoptotic levels as well as an accumulation on G1 phase in the transfected cells. These findings are concordant with RNASeq results showing and enrichment of deregulated genes in proliferation pathways as predicted by in silico analysis.