Fueling Cancer Immunotherapy with Genome editing

K B Benabdellah(1)

1:Fundacion Publica Andaluza Progreso y Salud/Genyo

Genome editing-based technologies not only provide unprecedented opportunities to study the basic functionality of the cellular system, but also improve the outcomes of various clinical applications. In our team, we are developing genome editing tools to improve the immune system from both clinical and basic research perspective.  During my talk we will discuss recent advances in the development of programmable nucleases, and their use for the improvement of immune cells.  In addition, we will describe how different gene editing tools have enabled the use of healthy donor cells in CAR T therapy instead of autologous cells, minimizing the risk of graft-versus-host disease or rejection. Finally, we will talk about a complementary approach, based on extra vesicles (EVs), and how these EVs can overcome some of the challenges that currently limit cancer immunotherapy