Patrocinadores de la SETGyC

Oro

BD

BD Biosciences is a world leader in bringing innovative diagnostic and research tools to life science researchers, clinical researchers, laboratory professionals and clinicians who are involved in basic research, drug discovery and development, biopharmaceutical production and disease management. The BD Biosciences segment is focused on continually advancing the science and applications associated with cellular analysis and products that help grow living cells and tissue. Products/Services · Fluorescence-activated cell sorters and analyzers · Monoclonal antibodies and kits for cell analysis · Reagent systems for life science research · Cell imaging systems · Laboratory products for tissue culture and fluid handling · Cell culture media and supplements for biopharmaceutical manufacturing

TERCEL

The Spanish cell therapy network (TerCel) is a collaborative research project organized by the Spanish National Institute of Health Carlos III that started in 2003, to promote research in cell therapy and translate the scientific advances in this field to the clinic. Based on a multidisciplinary approach and the interaction and cooperation between 33 groups of basic and clinical scientists across Spain, the main objective of TerCel is to develop new medical therapies based on the use of stem cells for cardiovascular diseases, neurodegenerative diseases and osteo-articular, immune-hematologic and metabolic diseases. www.red-tercel.com

TiGenix

TiGenix is a leading European cell therapy company with a commercial product and a strong clinical stage pipeline of adult stem cell programs. The company?s lead product, ChondroCelect®, for cartilage repair in the knee, is the only approved cell-based product in Europe, and is currently being launched across Europe. TiGenix?s adipose derived allogeneic stem cell platform has been extensively validated. TiGenix is based out of Leuven (Belgium) and has operations in Madrid (Spain), and Sittard-Geleen (the Netherlands).

Rocket

Rocket Pharma is a clinical-stage gene therapy company with a platform approach for the treatment of patients with high-unmet need rare diseases. We leverage lentiviral and AAV transduction strategies towards first-in-class programs.  Hallmarks of Rocket’s vision include: 1) a high threshold for the selection of quality programs, 2) leverage of deep industry know-how through a world-class team (Novartis Cell & Gene, Bluebird, BMS, others) and manufacturing partnerships (MolMed, PCT, others) and 3) a laser focus on optimizing gene therapy product parameters through a seasoned scientific approach that de-risks programs as they enter clinical trials.

VIVET Therapeutics

Vivet Therapeutics is a gene therapy biotech company with headquarters in Paris, France, dedicated to the research, development and future commercialization of gene therapy products for inherited liver disorders with high medical need.

Recently named as Fierce 15 biotech company, Vivet is committed to make a significant difference for patients facing rare metabolic diseases, with Wilson’s disease being our lead indication. Vivet has a strong presence in Spain through its research subsidiary and its strategic collaboration with Fundación para la Investigación Médica Aplicada (FIMA) at the Centro de Investigación Medica Aplicada (CIMA, University of Navarra, Spain), a leading research organization in the field of Gene Therapy. Vivet also has licensed the use of novel proprietary AAV vector gene therapy technology to treat metabolic diseases and certain patent-protected Anc80 AAV gene therapy vectors from Massachusetts Eye and Ear (MEE), a teaching hospital of Harvard Medical School, Boston. Anc80 is a next-generation gene therapy technology designed to increase gene expression levels in the liver.

Plata

VCN

VCN Biosciences is a privately-owned company focused in the development of new therapeutic approaches for tumors that lack effective treatment. The company uses oncolytic adenovirus technology platform to design highly selective and efficient agents that replicate and self-amplify exclusively in tumor cells. The selectivity of VCN oncolytic adenoviruses allows their systemic administration, which is especially relevant for the treatment of disseminated cancer. Contrary to chemotherapy, the ability of oncolytic virus to self-amplify in tumor cells results in an effective dose increase with time. These properties highlight VCN candidates as promising alternatives for the treatment of refractory tumors such as pancreatic adenocarcinomas, which is the current tumor target for its most advanced candidate, VCN-01.

vivebiotech

VIVEbiotech is a Company fully focused on Lentiviral vectors with two main activities: CDMO: GMP Contract Development and Manufacturing Organization specialized in Lentiviral vectors. VIVEbiotech is focused on the manufacture of Research, Preclinical toxicology and GMP-grade lentiviral vectors.
Sealed as Excellence Centre by European Union, VIVEbiotech is currently working with Companies based both in Europe and USA being our main aim adapting to customer requirements considering also planning and timelines related aspects.
Own Technology development: LENTISOMA: VIVEbiotech has developed its own worldwide licensed technology, a non-integrative episomal replicative lentiviral vector whose main advantage is associated to safety-related aspects

Biomarin

With six products on the market and a fully-integrated multinational organization in place, BioMarin is providing innovative therapeutics to patients with serious unmet medical needs. The company is also currently conducting a clinical trial of an AAV-based potential gene therapy for hemophilia A.

Euroclone

In the early 80s’ the establishment of CELBIO represented a true milestone, as this Company quickly became a reference for a number of scientists, giving them a valuable opportunity to gain access to a world of products and equipment in Biotechnology. Later on, this name became familiar also in the Medical and Diagnostic field. This leading approach remained unchanged and possibly improved throughout almost three decades, reinforcing the image of this Company as a reliable and solid partner for the entire scientific community.

At the beginning of the 90s' a sister Company called Euroclone® started its activity with the goal of giving more emphasis to the development of smart ideas which were felt to evolve into nice products to sell. The success was such that in 2009 it was decided to merge the two Companies, and CELBIO was fully incorporated into Euroclone®.

As a matter of fact, Euroclone® nowadays is bringing into the market the “passion” of the early days (since has inherited the Distribution of a panel of well known brands) along with a clear and growing interest in innovative and state-of-the art technologies originated by in-house R&D as well as obtained under private label and OEM agreement with the most qualifi ed manufacturers worldwide.

In other words, Euroclone® continues the tradition of CELBIO, while evolving into a modern supplier of up-to-date and own-branded products, thus reconfirming its position as a key-provider for a number of laboratories and clinics.

Viralgen

Viralgen vector Core is a new Company focused on GMP Development and Manufacturing of AAV. We are able to produce Research, Preclinical and GMP-grade batches. Our objective is became the CDMO leading in the sector of gene therapy and innovative medicines in Europe and US for developing and manufacturing in order to contribute to the progress in the health and welfare of people.

 

Audentes

Audentes Therapeutics is a clinical stage biotechnology company focused on developing and commercializing gene therapy products for patients living with serious, life-threatening rare diseases.  Audentes is currently developing four product candidates, including AT132 for the treatment of X-Linked Myotubular Myopathy (XLMTM), AT342 for the treatment of Crigler-Najjar Syndrome, AT982 for the treatment of Pompe disease, and AT307 for the treatment of the CASQ2 subtype of Catecholaminergic Polymorphic Ventricular Tachycardia (CASQ2-CPVT).  We are a focused, experienced and passionate team committed to forging strong, global relationships with the patient, research and medical communities.

Abeona

Abeona Therapeutics Inc. is a clinical-stage biopharmaceutical company developing gene therapies for life-threatening rare genetic diseases. Abeona's lead programs include ABO-102 (AAV-SGSH), an adeno-associated virus (AAV)-based gene therapy for Sanfilippo syndrome type A (MPS IIIA) and EB- 101 (gene-corrected skin grafts) for recessive dystrophic epidermolysis bullosa (RDEB). Abeona is also developing ABO-101 (AAV-NAGLU) for Sanfilippo syndrome type B (MPS IIIB), ABO-201 (AAV-CLN3) gene therapy for juvenile Batten disease (JNCL), ABO-202 (AAV-CLN1) for treatment of infantile Batten disease (INCL), EB-201 for epidermolysis bullosa (EB), ABO-301 (AAV- FANCC) for Fanconi anemia (FA) disorder and ABO-302 using a novel CRISPR/Cas9-based gene editing approach to gene therapy for rare blood diseases. In addition, Abeona is developing its proprietary vector platform, AIM™, for next generation product candidates.

Bronce

Genethon

Genethon, created by AFM-Telethon, has the mission to make innovative  gene therapy treatments available to patients affected with rare genetic diseases. To meet this challenge Genethon has assembled the technical and human resources needed to accelerate the medical application of scientific discoveries arising from fundamental research. Strong translational research programs engage multi-disciplinary teams and are supported by a first rate technological platform and cGMP facility

The pipeline of Genethon includes products currently in international clinical trials and at preclinical stages, for muscular dystrophies, immune deficiencies, blood, ocular and liver diseases. These products are developed either with Genethon as sponsor, or in partnership with private companies and academic institutions.

Eurofancolen

Fanconi anemia (FA) is a rare inherited syndrome characterized by the early development of bone marrow failure and increasing predisposition to cancer with age. Allogeneic hematopoietic cell transplantation (alloHCT) is the only curative therapy for hematopoietic manifestations of FA, although associated with complications arising from myeloablation, graft versus host disease and increased incidence of squamous cell carcinoma. The genetic correction of autologous hematopoietic stem cells (HSC) with lentiviral vectors constitutes a recent and safe alternative for the treatment of different genetic diseases affecting mature cells from different tissues and/or committed progenitors of the hematopoietic system. One of the key features of FA that make it a unique disease for gene therapy approaches rely on the characteristic proliferation defect that is already evident in the very primitive HSCs. Thus, a marked survival advantage would be expected from corrected HSCs, potentially allowing normalization of hematopoiesis in the absence or after mild conditioning. Difficulties in the collection of sufficient numbers of HSC from FA patients and the use of sub-optimal transduction protocols with gammaretroviral vectors limited the success of FA gene therapy trials conducted 10 years ago in the USA. EuroFancoLen innovative approach is to develop for the first time an efficient and safe gene therapy of FA based on two recent innovations: 1) Discovery of potent HSC mobilizers, such as plerixafor Ans 2) Development of a new lentiviral vector by members of this Consortium, designed as Orphan Drug by the Europan Commission in December 2010: The main objective of this project is, therefore, the development of a multicentric Phase I/II gene therapy trial for FA-A patients, based on the genetic correction of plerixafor+G-CSF mobilized HSCs with the novel lentiviral vector, accompanied by comprehensive and groundbreaking safety and efficacy patient monitoring estudies.

Ciberer

Rare diseases, affecting around 3 million Spanish people, are a social and health problem of the first order. The Centre for Biomedical Network Research on Rare Diseases (CIBERER), a network structure set up at the initiative of the Instituto de Salud Carlos III, pools and furthers the excellence research done in this country with the aim of finding diagnoses and therapies for those affected as quickly as possible.

Plasmid Factory

PlasmidFactory GmbH & Co. KG is a biopharmaceutical company, founded in Bielefeld in 2000.

Today the company is formed by a team of biologists, chemists, engineers and technicians. PlasmidFactory is the leading contract manufacturer of plasmid and minicircle DNA.

We produce your plasmids and minicircles according to your requirements in modern laboratories with high quality standards.

We are focussing R&D activities on our core competences: Production, analysis and storage of plasmid DNA.

At present, we are working on the following research topics – in close co-operation with industrial and academic partners.

  • Development of non-viral vector systems free of resistence gene sequences (minicircle)
  • Research on long-term storage of plasmid DNA and parameters influencing the stability (e.g. plasmid size, DNA concentration, storage buffer)
  • Influence of freeze and thaw conditions on plasmid topology
  • DNA vaccine development for cat fibrosarcoma
  • Production of dimer or multimer plasmids (e.g. reporter gene vectors)
  • Application of capillary gel electrophoresis (CGE) 
  • Optimization of vectors for co-transfection, e.g. for production of viruses (AAV, LV) or antibodies
  • Optimization of lentiviral vector systems
  • Vector development for hepatitis vaccines
  • Clinical and pre-clinical research for non-viral vectors
  • Microfluidic channel for separating minicircle and miniplasmids.